SIR1, an upstream component in auxin signaling identified by chemical genetics.

Science

Authors	Yunde Zhao Xinhua Dai Helen Blackwell Stuart Schreiber Joanne Chory
Keywords	Mutation Binding Sites Gene Expression Profiling Phenotype Oligonucleotide Array Sequence Analysis Signal Transduction Molecular Sequence Data Amino Acid Sequence Protein Structure, Tertiary Transcription, Genetic Sirtuins Adenosine Triphosphate Arabidopsis Benzamides Genes, Reporter Naphthols Plant Leaves Arabidopsis Proteins Gene Expression Regulation, Plant Genes, Plant Indoleacetic Acids Plant Roots
Abstract	Auxin is a plant hormone that regulates many aspects of plant growth and development. We used a chemical genetics approach to identify SIR1, a regulator of many auxin-inducible genes. The sir1 mutant was resistant to sirtinol, a small molecule that activates many auxin-inducible genes and promotes auxin-related developmental phenotypes. SIR1 is predicted to encode a protein composed of a ubiquitin-activating enzyme E1-like domain and a Rhodanese-like domain homologous to that of prolyl isomerase. We suggest a molecular context for how the auxin signal is propagated to exert its biological effects.
Year of Publication	2003
Journal	Science
Volume	301
Issue	5636
Pages	1107-10
Date Published	2003 Aug 22
ISSN	1095-9203
DOI	10.1126/science.1084161
PubMed ID	12893885
Links
Grant list	1R01GM68631-01 / GM / NIGMS NIH HHS / United States 2R01GM52413 / GM / NIGMS NIH HHS / United States

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