Doubling Down on Mutant RAS Can MEK or Break Leukemia.
Cell
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| Abstract | Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of Kras(G12D) mutant acute myeloid leukemia and propose its use as a predictive biomarker. |
| Year of Publication | 2017
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| Journal | Cell
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| Volume | 168
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| Issue | 5
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| Pages | 749-750
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| Date Published | 2017 02 23
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| ISSN | 1097-4172
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| DOI | 10.1016/j.cell.2017.02.013
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| PubMed ID | 28235190
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