Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair.
Mol Cell
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| Abstract | In this issue of Molecular Cell, Sivanand et al. (2017) describe the importance for nuclear ACLY-mediated production of acetyl-CoA, which promotes histone acetylation, BRCA1 recruitment, and subsequent HR-mediated DNA repair in response to DNA damage, thus drawing a direct link between DNA repair and cellular metabolism. |
| Year of Publication | 2017
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| Journal | Mol Cell
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| Volume | 67
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| Issue | 2
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| Pages | 165-167
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| Date Published | 2017 Jul 20
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| ISSN | 1097-4164
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| DOI | 10.1016/j.molcel.2017.07.006
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| PubMed ID | 28732204
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