Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.

Bioinformatics

Authors	Björn Nilsson Mikael Johansson Fatima Al-Shahrour Anne Carpenter Benjamin Ebert
Keywords	Gene Expression Profiling Chromosome Aberrations Computational Biology Algorithms Oligonucleotide Array Sequence Analysis Gene Dosage Polymorphism, Single Nucleotide
Abstract	MOTIVATION: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. RESULTS: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.
Year of Publication	2009
Journal	Bioinformatics
Volume	25
Issue	8
Pages	1078-9
Date Published	2009 Apr 15
ISSN	1367-4811
URL
DOI	10.1093/bioinformatics/btp091
PubMed ID	19228802
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