Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

Org Lett

Authors	Sameer Urgaonkar Henry La Pierre Israel Meir Henrik Lund Debabrata Raychaudhuri Jared Shaw
Keywords	Enzyme Inhibitors Anti-Bacterial Agents Bacterial Proteins Cytoskeletal Proteins Stereoisomerism Biological Products Chlorides Cytokinesis Flavanones GTP Phosphohydrolases Zinc Compounds
Abstract	[chemical structure: see text]. Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.
Year of Publication	2005
Journal	Org Lett
Volume	7
Issue	25
Pages	5609-12
Date Published	2005 Dec 08
ISSN	1523-7060
URL
DOI	10.1021/ol052269z
PubMed ID	16321003
PubMed Central ID	PMC2588422
Links
Grant list	R03 AI062905 / AI / NIAID NIH HHS / United States R03 AI062905-01 / AI / NIAID NIH HHS / United States R03 AI062905-02 / AI / NIAID NIH HHS / United States R01GM068025 / GM / NIGMS NIH HHS / United States

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