Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors.

Nat Genet

Authors	Juliann Chmielecki Aimee Crago Mara Rosenberg Rachael O'Connor Sarah Walker Lauren Ambrogio Daniel Auclair Aaron McKenna Michael Heinrich David Frank Matthew Meyerson
Keywords	Humans Base Sequence Neoplasm Proteins Molecular Sequence Data Genetic Variation Repressor Proteins Sequence Analysis, DNA Exome Gene Fusion Gene Components STAT6 Transcription Factor Solitary Fibrous Tumors
Abstract	Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs.
Year of Publication	2013
Journal	Nat Genet
Volume	45
Issue	2
Pages	131-2
Date Published	2013 Feb
ISSN	1546-1718
URL
DOI	10.1038/ng.2522
PubMed ID	23313954
PubMed Central ID	PMC3984043
Links
Grant list	P01 CA047179 / CA / NCI NIH HHS / United States P50 CA140146 / CA / NCI NIH HHS / United States P01CA47179 / CA / NCI NIH HHS / United States