Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder.

Epigenomics

Authors	Monica Uddin Andrew Ratanatharathorn Don Armstrong Pei-Fen Kuan Allison Aiello Evelyn Bromet Sandro Galea Karestan Koenen Benjamin Luft Kerry Ressler Derek Wildman Caroline Nievergelt Alicia Smith
Abstract	AIM: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD. MATERIALS & METHODS: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium. RESULTS: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098). CONCLUSION: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.
Year of Publication	2018
Journal	Epigenomics
Volume	10
Issue	12
Pages	1585-1601
Date Published	2018 Dec
ISSN	1750-192X
DOI	10.2217/epi-2018-0049
PubMed ID	30456986
PubMed Central ID	PMC6331697
Links
Grant list	P2C HD050924 / HD / NICHD NIH HHS / United States R01 MH108826 / MH / NIMH NIH HHS / United States U01 OH011478 / OH / NIOSH CDC HHS / United States R01 DA022720 / DA / NIDA NIH HHS / United States RC1 MH088283 / MH / NIMH NIH HHS / United States U01 OH010718 / OH / NIOSH CDC HHS / United States U01 OH010416 / OH / NIOSH CDC HHS / United States