SnapShot: Chronic Lymphocytic Leukemia.

Cancer Cell
Authors
Elisa Hacken
Romain Guièze
Catherine Wu
Keywords
Humans
Mutation
Genetic Predisposition to Disease
Disease Progression
Signal Transduction
Models, Genetic
B-Lymphocytes
Leukemia, Lymphocytic, Chronic, B-Cell
Tumor Microenvironment
Abstract

Despite the recent advances in the therapeutic management of Chronic Lymphocytic Leukemia (CLL) patients, this common B cell malignancy still remains incurable. This SnapShot provides an overview of CLL biology and therapy, with a focus on genetics and microenvironmental interactions, which contribute to disease progression and therapy resistance. To view this SnapShot, open or download the PDF.
Year of Publication
2017
Journal
Cancer Cell
Volume
32
Issue
5
Pages
716-716.e1
Date Published
2017 11 13
ISSN
1878-3686
DOI
10.1016/j.ccell.2017.10.015
PubMed ID
29136511
PubMed Central ID
PMC5858912
Links
Grant list
P01 CA206978 / CA / NCI NIH HHS / United States
R01 CA216273 / CA / NCI NIH HHS / United States
R01 HL131768 / HL / NHLBI NIH HHS / United States

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