GB virus C coinfections in west African Ebola patients.

J Virol

Authors	Michael Lauck Adam Bailey Kristian Andersen Tony Goldberg Pardis Sabeti David O'Connor
Keywords	Female Humans Male Adult Aged Middle Aged Survival Analysis Molecular Sequence Data Adolescent Child Infant Young Adult Sequence Analysis, DNA Child, Preschool Hemorrhagic Fever, Ebola Age Factors Aged, 80 and over Infant, Newborn RNA, Viral Coinfection Sierra Leone Flaviviridae Infections GB virus C Hepatitis, Viral, Human
Abstract	In 49 patients with known Ebola virus disease outcomes during the ongoing outbreak in Sierra Leone, 13 were coinfected with the immunomodulatory pegivirus GB virus C (GBV-C). Fifty-three percent of these GBV-C(+) patients survived; in contrast, only 22% of GBV-C(-) patients survived. Both survival and GBV-C status were associated with age, with older patients having lower survival rates and intermediate-age patients (21 to 45 years) having the highest rate of GBV-C infection. Understanding the separate and combined effects of GBV-C and age on Ebola virus survival may lead to new treatment and prevention strategies, perhaps through age-related pathways of immune activation.
Year of Publication	2015
Journal	J Virol
Volume	89
Issue	4
Pages	2425-9
Date Published	2015 Feb
ISSN	1098-5514
URL
DOI	10.1128/JVI.02752-14
PubMed ID	25473056
PubMed Central ID	PMC4338908
Links
Grant list	C06 RR020141 / RR / NCRR NIH HHS / United States C06 RR015459 / RR / NCRR NIH HHS / United States P51 RR000167 / RR / NCRR NIH HHS / United States RR15459-01 / RR / NCRR NIH HHS / United States T32 GM081061 / GM / NIGMS NIH HHS / United States RR020141-01 / RR / NCRR NIH HHS / United States R01 AI077376-01 / AI / NIAID NIH HHS / United States R01AI077376 / AI / NIAID NIH HHS / United States R01 AI077376 / AI / NIAID NIH HHS / United States P51RR000167 / RR / NCRR NIH HHS / United States T32 GM008692 / GM / NIGMS NIH HHS / United States T32 AI055397 / AI / NIAID NIH HHS / United States R01 AI098420 / AI / NIAID NIH HHS / United States