Disease-associated astrocytes in Alzheimer's disease and aging.
Nat Neurosci
| Authors | |
| Abstract | The role of non-neuronal cells in Alzheimer's disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer's disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors. |
| Year of Publication | 2020
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| Journal | Nat Neurosci
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| Date Published | 2020 Apr 27
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| ISSN | 1546-1726
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| DOI | 10.1038/s41593-020-0624-8
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| PubMed ID | 32341542
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| Links | |
| Grant list | 1250/18 / Israel Science Foundation (ISF)
913/15 / Israel Science Foundation (ISF)
991/16 / Israel Science Foundation (ISF)
U19MH114821 / U.S. Department of Health & Human Services | National Institutes of Health (NIH)
232835 / EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
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