Fast and accurate long-read assembly with wtdbg2.
Nat Methods
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| Abstract | Existing long-read assemblers require thousands of central processing unit hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a long-read assembler wtdbg2 () that is 2-17 times as fast as published tools while achieving comparable contiguity and accuracy. It paves the way for population-scale long-read assembly in future. |
| Year of Publication | 2020
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| Journal | Nat Methods
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| Volume | 17
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| Issue | 2
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| Pages | 155-158
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| Date Published | 2020 02
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| ISSN | 1548-7105
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| DOI | 10.1038/s41592-019-0669-3
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| PubMed ID | 31819265
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| PubMed Central ID | PMC7004874
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| Grant list | R01 HG010040 / HG / NHGRI NIH HHS / United States
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