Cell Specific eQTL Analysis without Sorting Cells.
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| Abstract | The functional consequences of trait associated SNPs are often investigated using expression quantitative trait locus (eQTL) mapping. While trait-associated variants may operate in a cell-type specific manner, eQTL datasets for such cell-types may not always be available. We performed a genome-environment interaction (GxE) meta-analysis on data from 5,683 samples to infer the cell type specificity of whole blood cis-eQTLs. We demonstrate that this method is able to predict neutrophil and lymphocyte specific cis-eQTLs and replicate these predictions in independent cell-type specific datasets. Finally, we show that SNPs associated with Crohn's disease preferentially affect gene expression within neutrophils, including the archetypal NOD2 locus. |
| Year of Publication | 2015
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| Journal | PLoS Genet
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| Volume | 11
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| Issue | 5
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| Pages | e1005223
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| Date Published | 2015 May
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| ISSN | 1553-7404
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| DOI | 10.1371/journal.pgen.1005223
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| PubMed ID | 25955312
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| PubMed Central ID | PMC4425538
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