Genetic ancestry contributes to somatic mutations in lung cancers from admixed Latin American populations.

Cancer Discov

Authors	Jian Carrot-Zhang Giovanny Soca-Chafre Nick Patterson Aaron Thorner Anwesha Nag Jacqueline Watson Giulio Genovese July Rodriguez Maya Gelbard Luis Corrales-Rodriguez Yoichiro Mitsuishi Gavin Ha Joshua Campbell Geoffrey Oxnard Oscar Arrieta Andres Cardona Alexander Gusev Matthew Meyerson
Abstract	Inherited lung cancer risk, particularly in non-smokers, is poorly understood. Genomic and ancestry analysis of 1153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden (TMB), and specific driver mutations in EGFR, KRAS, and STK11. A local Native American ancestry risk score was more strongly correlated with EGFR mutation frequency compared to global ancestry correlation, suggesting that germline genetics (rather than environmental exposure) underlie these disparities.
Year of Publication	2020
Journal	Cancer Discov
Date Published	2020 Dec 02
ISSN	2159-8290
DOI	10.1158/2159-8290.CD-20-1165
PubMed ID	33268447
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