Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.

Cell Stem Cell

Authors	Steven Hyman
Keywords	Humans Mutation Mental Disorders Models, Biological Synaptic Transmission Nerve Tissue Proteins Cell Adhesion Molecules, Neuronal
Abstract	Connecting rare genetic variants to neuropsychiatric disease mechanisms remains a significant challenge. In this issue of Cell Stem Cell, Pak et al. (2015) combine gene targeting and stem cell technologies to identify a significant cellular effect of rare penetrant NRXN1 mutations in human neurons, which was found to cause a defect in neurotransmitter release.
Year of Publication	2015
Journal	Cell Stem Cell
Volume	17
Issue	3
Pages	253-4
Date Published	2015 Sep 03
ISSN	1875-9777
URL
DOI	10.1016/j.stem.2015.08.013
PubMed ID	26340523
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