Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits.
Curr Diab Rep
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| Abstract | Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility. |
| Year of Publication | 2015
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| Journal | Curr Diab Rep
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| Volume | 15
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| Issue | 10
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| Pages | 83
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| Date Published | 2015 Oct
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| ISSN | 1539-0829
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| URL | |
| DOI | 10.1007/s11892-015-0648-8
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| PubMed ID | 26363598
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| PubMed Central ID | PMC4568008
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| Grant list | 086596/Z/08/Z / Wellcome Trust / United Kingdom
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