Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis.
Cancer Discov
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| Abstract | Cancer genotype-specific synthetic lethal vulnerabilities represent promising therapeutic targets. In this issue of Cancer Discovery, Ogiwara and colleagues uncover a synthetic lethal relationship between two histone acetyl transferase paralogs, CBP and p300, highlighting that cancer cells deficient in CBP are uniquely sensitized to genetic and chemical inhibition of p300. |
| Year of Publication | 2016
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| Journal | Cancer Discov
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| Volume | 6
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| Issue | 4
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| Pages | 350-2
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| Date Published | 2016 Apr
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| ISSN | 2159-8290
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| URL | |
| DOI | 10.1158/2159-8290.CD-16-0163
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| PubMed ID | 27045018
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| Grant list | DP2 CA195762 / CA / NCI NIH HHS / United States
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