Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Nat Genet
Authors
Aysu Okbay
Bart Baselmans
Jan-Emmanuel De Neve
Patrick Turley
Michel Nivard
Mark Fontana
S Fleur Meddens
Richard Linnér
Cornelius Rietveld
Jaime Derringer
Jacob Gratten
James Lee
Jimmy Liu
Ronald de Vlaming
Tarunveer Ahluwalia
Jadwiga Buchwald
Alana Cavadino
Alexis Frazier-Wood
Nicholas Furlotte
Victoria Garfield
Marie Geisel
Juan González
Saskia Haitjema
Robert Karlsson
Sander van der Laan
Karl-Heinz Ladwig
Jari Lahti
Sven Van der Lee
Penelope Lind
Tian Liu
Lindsay Matteson
Evelin Mihailov
Michael Miller
Camelia Minică
Ilja Nolte
Dennis Mook-Kanamori
Peter van der Most
Christopher Oldmeadow
Yong Qian
Olli Raitakari
Rajesh Rawal
Anu Realo
Rico Rueedi
Börge Schmidt
Albert Smith
Evie Stergiakouli
Toshiko Tanaka
Kent Taylor
Juho Wedenoja
Juergen Wellmann
Harm-Jan Westra
Sara Willems
Wei Zhao
LifeLines Cohort Study
Najaf Amin
Andrew Bakshi
Patricia Boyle
Samantha Cherney
Simon Cox
Gail Davies
Oliver Davis
Jun Ding
Nese Direk
Peter Eibich
Rebecca Emeny
Ghazaleh Fatemifar
Jessica Faul
Luigi Ferrucci
Andreas Forstner
Christian Gieger
Richa Gupta
Tamara Harris
Juliette Harris
Elizabeth Holliday
Jouke-Jan Hottenga
Philip De Jager
Marika Kaakinen
Eero Kajantie
Ville Karhunen
Ivana Kolcic
Meena Kumari
Lenore Launer
Lude Franke
Ruifang Li-Gao
Marisa Koini
Anu Loukola
Pedro Marques-Vidal
Grant Montgomery
Miriam Mosing
Lavinia Paternoster
Alison Pattie
Katja Petrovic
Laura Pulkki-Råback
Lydia Quaye
Katri Räikkönen
Igor Rudan
Rodney Scott
Jennifer Smith
Angelina Sutin
Maciej Trzaskowski
Anna Vinkhuyzen
Lei Yu
Delilah Zabaneh
John Attia
David Bennett
Klaus Berger
Lars Bertram
Dorret Boomsma
Harold Snieder
Shun-Chiao Chang
Francesco Cucca
Ian Deary
Cornelia van Duijn
Johan Eriksson
Ute Bültmann
Eco De Geus
Patrick Groenen
Vilmundur Gudnason
Torben Hansen
Catharine Hartman
Claire Haworth
Caroline Hayward
Andrew Heath
David Hinds
Elina Hyppönen
William Iacono
Marjo-Riitta Jarvelin
Karl-Heinz Jöckel
Jaakko Kaprio
Sharon Kardia
Liisa Keltikangas-Järvinen
Peter Kraft
Laura Kubzansky
Terho Lehtimäki
Patrik Magnusson
Nicholas Martin
Matt McGue
Andres Metspalu
Melinda Mills
Renée de Mutsert
Albertine Oldehinkel
Gerard Pasterkamp
Nancy Pedersen
Robert Plomin
Ozren Polasek
Christine Power
Stephen Rich
Frits Rosendaal
Hester Ruijter
David Schlessinger
Helena Schmidt
Rauli Svento
Reinhold Schmidt
Behrooz Alizadeh
Thorkild Sørensen
Tim Spector
Andrew Steptoe
Antonio Terracciano
A Roy Thurik
Nicholas Timpson
Henning Tiemeier
André Uitterlinden
Peter Vollenweider
Gert Wagner
David Weir
Jian Yang
Dalton Conley
George Smith
Albert Hofman
Magnus Johannesson
David Laibson
Sarah Medland
Michelle Meyer
Joseph Pickrell
Tõnu Esko
Robert Krueger
Jonathan Beauchamp
Philipp Koellinger
Daniel Benjamin
Meike Bartels
David Cesarini
Abstract

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Year of Publication
2016
Journal
Nat Genet
Volume
48
Issue
6
Pages
624-33
Date Published
2016 Jun
ISSN
1546-1718
URL
DOI
10.1038/ng.3552
PubMed ID
27089181
PubMed Central ID
PMC4884152
Links
Grant list
R01 DA036216 / DA / NIDA NIH HHS / United States
RF1 AG015819 / AG / NIA NIH HHS / United States
MC_UU_12013/3 / Medical Research Council / United Kingdom
R01 AG017917 / AG / NIA NIH HHS / United States
MR/J012165/1 / Medical Research Council / United Kingdom
UL1 TR000124 / TR / NCATS NIH HHS / United States
P30 DK063491 / DK / NIDDK NIH HHS / United States
MC_PC_15018 / Medical Research Council / United Kingdom
MC_UU_12013/1 / Medical Research Council / United Kingdom
MC_PC_U127561128 / Medical Research Council / United Kingdom
P01 AG005842 / AG / NIA NIH HHS / United States
R37 DA005147 / DA / NIDA NIH HHS / United States
UL1 TR001881 / TR / NCATS NIH HHS / United States
P30 AG012810 / AG / NIA NIH HHS / United States
R01 AG042568 / AG / NIA NIH HHS / United States
T32 AG000186 / AG / NIA NIH HHS / United States
647648 / European Research Council / International

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