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The Optical Profiling Platform (OPP) at the Ó³»­´«Ã½ aims to translate promising imaging methods from their inventors’ labs to the broader biological research community. The initial technique portfolio includes highly-multiplexed antigen detection, spatially resolved transcriptomics, and all-optical electrophysiology, each to be implemented in a variety of model systems. These tools offer unique, high-throughput portraits of cell identity and functional state but require advances in hardware capabilities; wetlab and measurement protocols; and, crucially, in computational infrastructure. I will discuss our progress on the experimental front while highlighting the analysis and engineering challenges involved in processing, interpreting, and integrating the resulting data.