Primer: The multiple testing problem
Neale Lab, Lander Lab, Ó³»´«Ã½; Analytic and Translational Genetics Unit, Massachusetts General Hospital
How do we control false positives when testing multiple hypotheses simultaneously? I will review the family-wise error rate (FWER), the false discovery rate (FDR) and related quantities, and discuss some classical and recent methods to control them. Highlights will include the (in)famous genome-wide significance threshold for association studies and Stephens's "New Deal."