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A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages.

Kimmerling RJ, Szeto GL, Li JW, et al. A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages. Nat Commun. 2016;7:10220. doi:10.1038/ncomms10220

Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction.

Klarenbeek PL, Doorenspleet ME, Esveldt REE, et al. Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction. PLoS One. 2015;10(10):e0140815. doi:10.1371/journal.pone.0140815

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.

Kim HJ, Barnitz A, Kreslavsky T, et al. Stable inhibitory activity of regulatory T cells requires the transcription factor Helios. Science. 2015;350(6258):334-9. doi:10.1126/science.aad0616

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function.

Chun E, Lavoie S, Michaud M, et al. CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function. Cell Rep. 2015;12(2):244-57. doi:10.1016/j.celrep.2015.06.024

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells.

Odorizzi PM, Pauken KE, Paley MA, Sharpe A, Wherry J. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. J Exp Med. 2015;212(7):1125-37. doi:10.1084/jem.20142237

Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.

Godec J, Cowley GS, Barnitz A, et al. Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation. Proc Natl Acad Sci U S A. 2015;112(2):512-7. doi:10.1073/pnas.1413291112

Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing.

Ziller MJ, Hansen KD, Meissner A, Aryee MJ. Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing. Nat Methods. 2015;12(3):230-2, 1 p following 232. doi:10.1038/nmeth.3152

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells.

Kurachi M, Barnitz A, Yosef N, et al. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol. 2014;15(4):373-83. doi:10.1038/ni.2834

In vivo discovery of immunotherapy targets in the tumour microenvironment.

Zhou P, Shaffer DR, Arias DAA, et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014;506(7486):52-7. doi:10.1038/nature12988

Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection.

Henn MR, Boutwell CL, Charlebois P, et al. Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection. PLoS Pathog. 2012;8(3):e1002529. doi:10.1371/journal.ppat.1002529