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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Chen PJ, Hussmann JA, Yan J, et al. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021;184(22):5635-5652.e29. doi:10.1016/j.cell.2021.09.018

OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.

Vetere A, Li WC, Paroni F, et al. OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. Diabetologia. 2010;53(1):115-22. doi:10.1007/s00125-009-1567-5

Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70.

Graef IA, Holsinger LJ, Diver S, Schreiber SL, Crabtree GR. Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. EMBO J. 1997;16(18):5618-28. doi:10.1093/emboj/16.18.5618

Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition.

DeRan M, Pulvino M, Greene E, Su C, Zhao J. Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition. Mol Cell Biol. 2008;28(1):435-47. doi:10.1128/MCB.00607-07

Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.

Pulvino M, Liang Y, Oleksyn D, et al. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood. 2012;120(8):1668-77. doi:10.1182/blood-2012-02-406074

Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma.

Chen EY, DeRan MT, Ignatius MS, et al. Glycogen synthase kinase 3 inhibitors induce the canonical WNT/β-catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2014;111(14):5349-54. doi:10.1073/pnas.1317731111

Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.

Chan P, Han X, Zheng B, et al. Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway. Nat Chem Biol. 2016;12(4):282-9. doi:10.1038/nchembio.2036

Prevention of HIV-1 infection and preservation of CD4 function by the binding of CPFs to gp120.

Finberg RW, Diamond DC, Mitchell DB, et al. Prevention of HIV-1 infection and preservation of CD4 function by the binding of CPFs to gp120. Science. 1990;249(4966):287-91.

Signal transduction in T lymphocytes using a conditional allele of Sos.

Holsinger LJ, Spencer DM, Austin DJ, Schreiber SL, Crabtree GR. Signal transduction in T lymphocytes using a conditional allele of Sos. Proc Natl Acad Sci U S A. 1995;92(21):9810-4.

Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists.

Ho SN, Boyer SH, Schreiber SL, Danishefsky SJ, Crabtree GR. Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists. Proc Natl Acad Sci U S A. 1994;91(20):9203-7.