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      1. Carlos Slim Center for Health Research The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.
      2. Gerstner Center for Cancer Diagnostics The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.
      3. Klarman Cell Observatory The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.
      4. Merkin Institute for Transformative Technologies in Healthcare The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.
      5. Novo Nordisk Foundation Center for Genomic Mechanisms of Disease This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the ӳý and the Danish research community.
      6. Eric and Wendy Schmidt Center The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.
      7. Stanley Center for Psychiatric Research The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.
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      1. Art and science connection Explore the connection between art and science and how we bring together artists and ӳý scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations.
      2. ӳý Discovery Center Visit our free public educational space that showcases how researchers at the ӳý and their colleagues around the world seek to understand and treat human disease.
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The phospholipid PI(3,4)P is an apical identity determinant.
Román-Fernández Á, Roignot J, Sandilands E, et al. The phospholipid PI(3,4)P is an apical identity determinant. Nat Commun. 2018;9(1):5041. doi:10.1038/s41467-018-07464-8
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Presence of thoracic and lumbar vertebral malformations in pugs with and without chronic neurological deficits.
Rohdin C, Häggström J, Ljungvall I, et al. Presence of thoracic and lumbar vertebral malformations in pugs with and without chronic neurological deficits. Vet J. 2018;241:24-30. doi:10.1016/j.tvjl.2018.09.008
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The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.
Xiong Y, Wiltsie J, Woods A, et al. The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006;16(4):964-8. doi:10.1016/j.bmcl.2005.10.088
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Hepatotrophic properties in dogs of human FKBP, the binding protein for FK506 and rapamycin.
Starzl TE, Schreiber SL, Albers MW, Porter KA, Foglieni CS, Francavilla A. Hepatotrophic properties in dogs of human FKBP, the binding protein for FK506 and rapamycin. Transplantation. 1991;52(4):751-3.
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Effect of sodium nitrate loading on electrolyte transport by the renal tubule.
Kahn T, Bosch J, Levitt MF, Goldstein MH. Effect of sodium nitrate loading on electrolyte transport by the renal tubule. Am J Physiol. 1975;229(3):746-53.
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America's lost dogs.
Goodman L, Karlsson EK. America’s lost dogs. Science. 2018;361(6397):27-28. doi:10.1126/science.aau1306
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An exome sequencing based approach for genome-wide association studies in the dog.
Broeckx BJG, Derrien T, Mottier S, et al. An exome sequencing based approach for genome-wide association studies in the dog. Sci Rep. 2017;7(1):15680. doi:10.1038/s41598-017-15947-9
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Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Gaya M, Barral P, Burbage M, et al. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells. Cell. 2018;172(3):517-533.e20. doi:10.1016/j.cell.2017.11.036
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High prevalence of gait abnormalities in pugs.
Rohdin C, Jäderlund KH, Ljungvall I, Lindblad-Toh K, Häggström J. High prevalence of gait abnormalities in pugs. Vet Rec. 2018;182(6):167. doi:10.1136/vr.104510
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p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity.
Frank SR, Köllmann CP, Luong P, et al. p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity. J Cell Biol. 2018;217(9):3183-3201. doi:10.1083/jcb.201710058
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In March of 2020, ӳý converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

ӳý Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through ӳý's Scientists in the Classroom program, ӳý researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at ӳý working side-by-side with mentors on cutting-edge research.

In November 2022, ӳý’s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, ӳý’s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, ӳý has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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