Drug Design

Chemical biology and bacteria: not simply a matter of life or death.

Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006;10(4):321-6. doi:10.1016/j.cbpa.2006.06.016

The resurgence of phenotypic screening in drug discovery and development.

Wagner BK. The resurgence of phenotypic screening in drug discovery and development. Expert Opin Drug Discov. 2016;11(2):121-5. doi:10.1517/17460441.2016.1122589

Targeting the pancreatic β-cell to treat diabetes.

Vetere A, Choudhary A, Burns SM, Wagner BK. Targeting the pancreatic β-cell to treat diabetes. Nat Rev Drug Discov. 2014;13(4):278-89. doi:10.1038/nrd4231

Engineering a ligand-dependent RNA transcriptional activator.

Buskirk AR, Landrigan A, Liu DR. Engineering a ligand-dependent RNA transcriptional activator. Chem Biol. 2004;11(8):1157-63. doi:10.1016/j.chembiol.2004.05.017

Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines.

Geng B, Basarab G, Comita-Prevoir J, et al. Potent and selective inhibitors of Helicobacter pylori glutamate racemase (MurI): pyridodiazepine amines. Bioorg Med Chem Lett. 2009;19(3):930-6. doi:10.1016/j.bmcl.2008.11.113

Organic synthesis toward small-molecule probes and drugs.

Schreiber SL. Organic synthesis toward small-molecule probes and drugs. Proc Natl Acad Sci U S A. 2011;108(17):6699-702. doi:10.1073/pnas.1103205108

Organic chemistry: Molecular diversity by design.

Schreiber SL. Organic chemistry: Molecular diversity by design. Nature. 2009;457(7226):153-4. doi:10.1038/457153a

Stuart Schreiber: biology from a chemist's perspective. Interview by Joanna Owens.

Schreiber SL. Stuart Schreiber: biology from a chemist’s perspective. Interview by Joanna Owens. Drug Discov Today. 2004;9(7):299-303. doi:10.1016/S1359-6446(04)03063-6

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