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      1. Carlos Slim Center for Health Research The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.
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      5. Novo Nordisk Foundation Center for Genomic Mechanisms of Disease This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Ó³»­´«Ã½ and the Danish research community.
      6. Eric and Wendy Schmidt Center The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.
      7. Stanley Center for Psychiatric Research The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.
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      1. Art and science connection Explore the connection between art and science and how we bring together artists and Ó³»­´«Ã½ scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations.
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Post-transcriptional splicing can occur in a slow-moving zone around the gene.
Coté A, O’Farrell A, Dardani I, et al. Post-transcriptional splicing can occur in a slow-moving zone around the gene. eLife. 2024;12. doi:10.7554/eLife.91357
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Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression.
Gao P, Lyu Q, Ghanam A, et al. Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression. Genome biology. 2021;22(1):83. doi:10.1186/s13059-021-02304-3
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DNA methylation-environment interactions in the human genome.
Johnston RA, Aracena KA, Barreiro LB, Lea AJ, Tung J. DNA methylation-environment interactions in the human genome. eLife. 2024;12. doi:10.7554/eLife.89371
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De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors.
Akshay A, Gheinani AH, Besic M, et al. De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors. BMC urology. 2024;24(1):33. doi:10.1186/s12894-024-01417-8
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Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits.
Wittich H, Ardlie K, Taylor KD, et al. Transcriptome-wide association study of the plasma proteome reveals cis and trans regulatory mechanisms underlying complex traits. American journal of human genetics. 2024. doi:10.1016/j.ajhg.2024.01.006
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Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging.
Braunger JM, Cammarata L V, Sornapudi TR, Uhler C, Shivashankar G V. Transcriptional changes are tightly coupled to chromatin reorganization during cellular aging. Aging cell. 2023:e14056. doi:10.1111/acel.14056
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Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects.
Kasela S, Aguet F, Kim-Hellmuth S, et al. Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects. American journal of human genetics. 2024;111(1):133-149. doi:10.1016/j.ajhg.2023.11.013
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Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traits.
Li J, Zhao T, Guan D, et al. Learning functional conservation between human and pig to decipher evolutionary mechanisms underlying gene expression and complex traits. Cell genomics. 2023;3(10):100390. doi:10.1016/j.xgen.2023.100390
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MAUDE: inferring expression changes in sorting-based CRISPR screens.
de Boer CG, Ray JP, Hacohen N, Regev A. MAUDE: inferring expression changes in sorting-based CRISPR screens. Genome Biol. 2020;21(1):134. doi:10.1186/s13059-020-02046-8
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Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma.
Tome-Garcia J, Erfani P, Nudelman G, et al. Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma. Nat Commun. 2018;9(1):4020. doi:10.1038/s41467-018-06258-2
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In March of 2020, Ó³»­´«Ã½ converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Ó³»­´«Ã½ Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Ó³»­´«Ã½'s Scientists in the Classroom program, Ó³»­´«Ã½ researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Ó³»­´«Ã½ working side-by-side with mentors on cutting-edge research.

In November 2022, Ó³»­´«Ã½â€™s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Ó³»­´«Ã½â€™s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Ó³»­´«Ã½ has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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