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Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences.

Pugh TJ, Yu W, Yang J, et al. Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences. Oncogene. 2014;33(45):5295-302. doi:10.1038/onc.2014.150

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation.

Shalek AK, Satija R, Shuga J, et al. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation. Nature. 2014;510(7505):363-9. doi:10.1038/nature13437

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.

Patel AP, Tirosh I, Trombetta JJ, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014;344(6190):1396-401. doi:10.1126/science.1254257

Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo.

Grgic I, Hofmeister AF, Genovese G, et al. Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo. Kidney Int. 2014;86(6):1116-29. doi:10.1038/ki.2014.204

Functional divergence of the miRNA transcriptome at the onset of Drosophila metamorphosis.

Yeh SD, von Grotthuss M, Gandasetiawan KA, et al. Functional divergence of the miRNA transcriptome at the onset of Drosophila metamorphosis. Mol Biol Evol. 2014;31(10):2557-72. doi:10.1093/molbev/msu195

Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster.

Slattery M, Ma L, Spokony RF, et al. Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster. Genome Res. 2014;24(7):1224-35. doi:10.1101/gr.168807.113

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.

Wawer MJ, Li K, Gustafsdottir SM, et al. Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. Proc Natl Acad Sci U S A. 2014;111(30):10911-6. doi:10.1073/pnas.1410933111

Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.

Seiwert TY, Zuo Z, Keck MK, et al. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer Res. 2015;21(3):632-41. doi:10.1158/1078-0432.CCR-13-3310

Multivariate inference of pathway activity in host immunity and response to therapeutics.

Goel G, Conway KL, Jaeger M, Netea MG, Xavier RJ. Multivariate inference of pathway activity in host immunity and response to therapeutics. Nucleic Acids Res. 2014;42(16):10288-306. doi:10.1093/nar/gku722

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, et al. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014;158(5):1094-109. doi:10.1016/j.cell.2014.07.032