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Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.

Wang YH, Israelsen WJ, Lee D, et al. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 2014;158(6):1309-23. doi:10.1016/j.cell.2014.07.048

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

Cheng SC, Quintin J, Cramer RA, et al. mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014;345(6204):1250684. doi:10.1126/science.1250684

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.

Palsson-McDermott EM, Curtis AM, Goel G, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21(1):65-80. doi:10.1016/j.cmet.2014.12.005

Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.

Oldham WM, Clish CB, Yang Y, Loscalzo J. Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress. Cell Metab. 2015;22(2):291-303. doi:10.1016/j.cmet.2015.06.021

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

Kugel S, Feldman JL, Klein MA, et al. Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer. Cell Rep. 2015;13(3):479-88. doi:10.1016/j.celrep.2015.09.022

Distinct physiological states of Plasmodium falciparum in malaria-infected patients.

Daily JP, Scanfeld D, Pochet N, et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 2007;450(7172):1091-5. doi:10.1038/nature06311

Direct control of mitochondrial function by mTOR.

Ramanathan A, Schreiber SL. Direct control of mitochondrial function by mTOR. Proc Natl Acad Sci U S A. 2009;106(52):22229-32. doi:10.1073/pnas.0912074106