ӳ��ý

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Warren CR, O’Sullivan JF, Friesen M, et al. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017;20(4):547-557.e7. doi:10.1016/j.stem.2017.01.010

Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.

Pashos EE, Park Y, Wang X, et al. Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci. Cell Stem Cell. 2017;20(4):558-570.e10. doi:10.1016/j.stem.2017.03.017

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

Sharabi K, Lin H, Tavares CDJ, et al. Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017;169(1):148-160.e15. doi:10.1016/j.cell.2017.03.001

Synthesis, characterization, and preliminary biological study of glycoconjugates of poly(styrene-co-maleic acid).

Donati I, Gamini A, Vetere A, Campa C, Paoletti S. Synthesis, characterization, and preliminary biological study of glycoconjugates of poly(styrene-co-maleic acid). Biomacromolecules. 2002;3(4):805-12.

Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression.

Nagiec MM, Skepner AP, Negri J, et al. Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. PLoS One. 2015;10(3):e0120295. doi:10.1371/journal.pone.0120295

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Dayton TL, Gocheva V, Miller KM, et al. Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes Dev. 2016;30(9):1020-33. doi:10.1101/gad.278549.116

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax.

March S, Ng S, Velmurugan S, et al. A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax. Cell Host Microbe. 2013;14(1):104-15. doi:10.1016/j.chom.2013.06.005

Cannabinoid receptor signaling regulates liver development and metabolism.

Liu LY, Alexa K, Cortes M, et al. Cannabinoid receptor signaling regulates liver development and metabolism. Development. 2016;143(4):609-22. doi:10.1242/dev.121731

Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification.

Logan DJ, Shan J, Bhatia SN, Carpenter AE. Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification. Methods. 2016;96:6-11. doi:10.1016/j.ymeth.2015.12.002

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

March S, Ramanan V, Trehan K, et al. Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens. Nat Protoc. 2015;10(12):2027-53. doi:10.1038/nprot.2015.128