ӳ��ý

Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.

Neale BM, Sklar P. Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation. Curr Opin Neurobiol. 2015;30:131-8. doi:10.1016/j.conb.2014.12.001

Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts.

Würtz P, Havulinna AS, Soininen P, et al. Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts. Circulation. 2015;131(9):774-85. doi:10.1161/CIRCULATIONAHA.114.013116

No evidence for association of autism with rare heterozygous point mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins.

Murdoch JD, Gupta AR, Sanders SJ, et al. No evidence for association of autism with rare heterozygous point mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins. PLoS Genet. 2015;11(1):e1004852. doi:10.1371/journal.pgen.1004852

Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction.

Thormaehlen AS, Schuberth C, Won HH, et al. Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction. PLoS Genet. 2015;11(2):e1004855. doi:10.1371/journal.pgen.1004855

Massively expedited genome-wide heritability analysis (MEGHA).

Ge T, Nichols TE, Lee PH, et al. Massively expedited genome-wide heritability analysis (MEGHA). Proc Natl Acad Sci U S A. 2015;112(8):2479-84. doi:10.1073/pnas.1415603112

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.

Jeong SM, Xiao C, Finley LWS, et al. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 2013;23(4):450-63. doi:10.1016/j.ccr.2013.02.024

Cutting the Gordian helix--regulating genomic testing in the era of precision medicine.

Lander ES. Cutting the Gordian helix--regulating genomic testing in the era of precision medicine. N Engl J Med. 2015;372(13):1185-6. doi:10.1056/NEJMp1501964

Highly efficient Cas9-mediated transcriptional programming.

Chavez A, Scheiman J, Vora S, et al. Highly efficient Cas9-mediated transcriptional programming. Nat Methods. 2015;12(4):326-8. doi:10.1038/nmeth.3312

Discovery of novel rhabdoviruses in the blood of healthy individuals from West Africa.

Stremlau MH, Andersen KG, Folarin OA, et al. Discovery of novel rhabdoviruses in the blood of healthy individuals from West Africa. PLoS Negl Trop Dis. 2015;9(3):e0003631. doi:10.1371/journal.pntd.0003631

The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes.

Walford GA, Colomo N, Todd JN, et al. The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes. PLoS One. 2015;10(3):e0121553. doi:10.1371/journal.pone.0121553