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Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke.

Tada H, Shiffman D, Smith G, et al. Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke. Stroke. 2014;45(10):2856-62. doi:10.1161/STROKEAHA.114.006072

Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain.

Cai X, Evrony GD, Lehmann HS, et al. Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain. Cell Rep. 2014;8(5):1280-9. doi:10.1016/j.celrep.2014.07.043

Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?

Levinson DF, Mostafavi S, Milaneschi Y, et al. Genetic studies of major depressive disorder: why are there no genome-wide association study findings and what can we do about it?. Biol Psychiatry. 2014;76(7):510-2. doi:10.1016/j.biopsych.2014.07.029

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.

Bejar R, Lord A, Stevenson K, et al. TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood. 2014;124(17):2705-12. doi:10.1182/blood-2014-06-582809

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.

Mayers JR, Wu C, Clish CB, et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med. 2014;20(10):1193-8. doi:10.1038/nm.3686

Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium.

Taylor AE, Fluharty ME, Bjørngaard JH, et al. Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. BMJ Open. 2014;4(10):e006141. doi:10.1136/bmjopen-2014-006141

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.

Tan L, Wang J, Tanizaki J, et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014;111(45):E4869-77. doi:10.1073/pnas.1403438111

Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha.

Ben-David U, Cowell IG, Austin CA, Benvenisty N. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015;33(3):1013-9. doi:10.1002/stem.1888

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

Wainger BJ, Buttermore ED, Oliveira JT, et al. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015;18(1):17-24. doi:10.1038/nn.3886

A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin States.

Bornstein C, Winter D, Barnett-Itzhaki Z, et al. A negative feedback loop of transcription factors specifies alternative dendritic cell chromatin States. Mol Cell. 2014;56(6):749-62. doi:10.1016/j.molcel.2014.10.014