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An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Marcaurelle LA, Comer E, Dandapani S, et al. An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors. J Am Chem Soc. 2010;132(47):16962-76. doi:10.1021/ja105119r

cAMP-response element modulator-tau activates a distinct promoter element for the expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene.

Tramer F, Vetere A, Martinelli M, et al. cAMP-response element modulator-tau activates a distinct promoter element for the expression of the phospholipid hydroperoxide/sperm nucleus glutathione peroxidase gene. Biochem J. 2004;383(Pt 1):179-85. doi:10.1042/BJ20040974

OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.

Vetere A, Li WC, Paroni F, et al. OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. Diabetologia. 2010;53(1):115-22. doi:10.1007/s00125-009-1567-5

Novel fluorescent cycloheximide derivatives for the imaging of protein synthesis.

Paoletti F, Ainger K, Donati I, et al. Novel fluorescent cycloheximide derivatives for the imaging of protein synthesis. Biochem Biophys Res Commun. 2010;396(2):258-64. doi:10.1016/j.bbrc.2010.04.075

Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP.

Miller E, Yang J, DeRan M, et al. Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. Chem Biol. 2012;19(8):955-62. doi:10.1016/j.chembiol.2012.07.005

2-Bromopalmitate analogues as activity-based probes to explore palmitoyl acyltransferases.

Zheng B, DeRan M, Li X, Liao X, Fukata M, Wu X. 2-Bromopalmitate analogues as activity-based probes to explore palmitoyl acyltransferases. J Am Chem Soc. 2013;135(19):7082-5. doi:10.1021/ja311416v

Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway.

Li G, Diogo D, Wu D, et al. Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway. PLoS Genet. 2013;9(5):e1003487. doi:10.1371/journal.pgen.1003487

Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70.

Graef IA, Holsinger LJ, Diver S, Schreiber SL, Crabtree GR. Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. EMBO J. 1997;16(18):5618-28. doi:10.1093/emboj/16.18.5618

Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions.

Weng Z, Rickles RJ, Feng S, et al. Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions. Mol Cell Biol. 1995;15(10):5627-34.

Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12.

Kaye RE, Fruman DA, Bierer BE, et al. Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. Proc Natl Acad Sci U S A. 1992;89(18):8542-6.