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Cryo-EM structure of a fungal mitochondrial calcium uniporter.

Nguyen NX, Armache JP, Lee C, et al. Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature. 2018;559(7715):570-574. doi:10.1038/s41586-018-0333-6

Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein.

Botuyan MV, Cui G, Drané P, et al. Mechanism of 53BP1 activity regulation by RNA-binding TIRR and a designer protein. Nat Struct Mol Biol. 2018;25(7):591-600. doi:10.1038/s41594-018-0083-z

Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription.

Belashov IA, Crawford DW, Cavender CE, et al. Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription. Nucleic Acids Res. 2018;46(13):6401-6415. doi:10.1093/nar/gky529

2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors.

Hua Z, Huang X, Bregman H, et al. 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors. Bioorg Med Chem Lett. 2012;22(17):5392-5. doi:10.1016/j.bmcl.2012.07.046

A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin.

Ranaghan MJ, Kumar RP, Chakrabarti KS, Buosi V, Kern D, Oprian DD. A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin. J Biol Chem. 2013;288(50):36160-7. doi:10.1074/jbc.M113.524355

Engineering of CRISPR-Cas12b for human genome editing.

Strecker J, Jones S, Koopal B, et al. Engineering of CRISPR-Cas12b for human genome editing. Nat Commun. 2019;10(1):212. doi:10.1038/s41467-018-08224-4

Rare coding variants in genes encoding GABA receptors in genetic generalised epilepsies: an exome-based case-control study.

May P, Girard S, Harrer M, et al. Rare coding variants in genes encoding GABA receptors in genetic generalised epilepsies: an exome-based case-control study. Lancet Neurol. 2018;17(8):699-708. doi:10.1016/S1474-4422(18)30215-1

The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B.

Shen H, Campanello GC, Flicker D, et al. The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B. Cell. 2017;171(4):771-782.e11. doi:10.1016/j.cell.2017.09.051

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

Shen K, Choe A, Sabatini DM. Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability. Mol Cell. 2017;68(3):552-565.e8. doi:10.1016/j.molcel.2017.09.026

DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome.

Marsh APL, Edwards TJ, Galea C, et al. DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome. Hum Mutat. 2018;39(1):23-39. doi:10.1002/humu.23361