Gruen M, Chang K, Serbanescu I, Liu DR. An in vivo selection system for homing endonuclease activity. Nucleic Acids Res. 2002;30(7):e29.
Bittker JA, Le BV, Liu JM, Liu DR. Directed evolution of protein enzymes using nonhomologous random recombination. Proc Natl Acad Sci U S A. 2004;101(18):7011-6. doi:10.1073/pnas.0402202101
Doyon JB, Pattanayak V, Meyer CB, Liu DR. Directed evolution and substrate specificity profile of homing endonuclease I-SceI. J Am Chem Soc. 2006;128(7):2477-84. doi:10.1021/ja057519l
Fischbach MA, Lai JR, Roche ED, Walsh CT, Liu DR. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proc Natl Acad Sci U S A. 2007;104(29):11951-6. doi:10.1073/pnas.0705348104
Karanicolas J, Corn JE, Chen I, et al. A de novo protein binding pair by computational design and directed evolution. Mol Cell. 2011;42(2):250-60. doi:10.1016/j.molcel.2011.03.010
Peck SH, Chen I, Liu DR. Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells. Chem Biol. 2011;18(5):619-30. doi:10.1016/j.chembiol.2011.02.014
Georghiou G, Kleiner RE, Pulkoski-Gross M, Liu DR, Seeliger MA. Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles. Nat Chem Biol. 2012;8(4):366-74. doi:10.1038/nchembio.792
Accili D, Frapier C, Mosthaf L, et al. A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes. EMBO J. 1989;8(9):2509-17.
Dickinson BC, Packer MS, Badran AH, Liu DR. A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations. Nat Commun. 2014;5:5352. doi:10.1038/ncomms6352
Badran AH, Liu DR. Development of potent in vivo mutagenesis plasmids with broad mutational spectra. Nat Commun. 2015;6:8425. doi:10.1038/ncomms9425