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Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.

Nehme R, Zuccaro E, Ghosh SD, et al. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Rep. 2018;23(8):2509-2523. doi:10.1016/j.celrep.2018.04.066

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.

Ordureau A, Paulo JA, Zhang W, et al. Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Mol Cell. 2018;70(2):211-227.e8. doi:10.1016/j.molcel.2018.03.012

The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection.

Markowitz JE, Gillis WF, Beron CC, et al. The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection. Cell. 2018;174(1):44-58.e17. doi:10.1016/j.cell.2018.04.019

Resolving medulloblastoma cellular architecture by single-cell genomics.

Hovestadt V, Smith KS, Bihannic L, et al. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019;572(7767):74-79. doi:10.1038/s41586-019-1434-6

Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes.

Guo SM, Veneziano R, Gordonov S, et al. Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes. Nat Commun. 2019;10(1):4377. doi:10.1038/s41467-019-12372-6

Aging and neurodegeneration are associated with increased mutations in single human neurons.

Lodato MA, Rodin RE, Bohrson CL, et al. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 2018;359(6375):555-559. doi:10.1126/science.aao4426

Hippocampal oxytocin receptors are necessary for discrimination of social stimuli.

Raam T, McAvoy KM, Besnard A, Veenema AH, Sahay A. Hippocampal oxytocin receptors are necessary for discrimination of social stimuli. Nat Commun. 2017;8(1):2001. doi:10.1038/s41467-017-02173-0

A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility.

Yuskaitis CJ, Jones BM, Wolfson RL, et al. A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility. Neurobiol Dis. 2018;111:91-101. doi:10.1016/j.nbd.2017.12.010

Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias.

D’Gama AM, Woodworth MB, Hossain AA, et al. Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias. Cell Rep. 2017;21(13):3754-3766. doi:10.1016/j.celrep.2017.11.106

All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.

Fan LZ, Nehme R, Adam Y, et al. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods. 2018;15(10):823-831. doi:10.1038/s41592-018-0142-8