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      1. Disease areas Ó³»­´«Ã½ brings people together to advance the understanding and treatment of disease.
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      2. Research areas Through programs spanning genetics, biology, artificial intelligence (AI), and therapeutic development, Ó³»­´«Ã½ researchers are making discoveries that drive biomedical science forward.
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        1. Patient-partnered research Patients partner with our scientists to accelerate the pace of discovery and find better treatments.
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      1. Carlos Slim Center for Health Research The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.
      2. Gerstner Center for Cancer Diagnostics The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.
      3. Klarman Cell Observatory The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.
      4. Merkin Institute for Transformative Technologies in Healthcare The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.
      5. Novo Nordisk Foundation Center for Genomic Mechanisms of Disease This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Ó³»­´«Ã½ and the Danish research community.
      6. Eric and Wendy Schmidt Center The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.
      7. Stanley Center for Psychiatric Research The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.
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      1. Art and science connection Explore the connection between art and science and how we bring together artists and Ó³»­´«Ã½ scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations.
      2. Ó³»­´«Ã½ Discovery Center Visit our free public educational space that showcases how researchers at the Ó³»­´«Ã½ and their colleagues around the world seek to understand and treat human disease.
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Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.
Holman CD, Sakers AP, Calhoun RP, et al. Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming. eLife. 2024;12. doi:10.7554/eLife.87756
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Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells.
Dellorusso P V, Proven MA, Calero-Nieto FJ, et al. Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells. Cell stem cell. 2024. doi:10.1016/j.stem.2024.04.020
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Clonal Hematopoiesis Among Patients With Asymptomatic Carotid Stenosis Compounds Risk of Cardiovascular Death.
Natarajan P, Bellomo TR. Clonal Hematopoiesis Among Patients With Asymptomatic Carotid Stenosis Compounds Risk of Cardiovascular Death. Journal of the American College of Cardiology. 2024;83(18):1728-1730. doi:10.1016/j.jacc.2024.03.389
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Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS.
Gete Y, Koblan LW, Mao X, et al. Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS. Aging cell. 2021;20(7):e13388. doi:10.1111/acel.13388
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Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.
Mitchell W, Goeminne LJE, Tyshkovskiy A, et al. Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation. eLife. 2024;12. doi:10.7554/eLife.90579
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Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.
Ganz J, Luquette LJ, Bizzotto S, et al. Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes. Cell. 2024. doi:10.1016/j.cell.2024.02.025
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Associations of brain morphology with cortical proteins of cognitive resilience.
Poole VN, Ridwan AR, Arfanakis K, et al. Associations of brain morphology with cortical proteins of cognitive resilience. Neurobiology of aging. 2024;137:1-7. doi:10.1016/j.neurobiolaging.2024.02.005
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Implications of metabolism on multi-systems healthy aging across the lifespan.
Yao S, Colangelo LA, Perry AS, et al. Implications of metabolism on multi-systems healthy aging across the lifespan. Aging cell. 2024:e14090. doi:10.1111/acel.14090
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Associations between Walking Speed and Gut Microbiome Composition in Older Men from the MrOS Study.
Farsijani S, Cauley JA, Cawthon PM, et al. Associations between Walking Speed and Gut Microbiome Composition in Older Men from the MrOS Study. The journals of gerontology. Series A, Biological sciences and medical sciences. 2024. doi:10.1093/gerona/glae030
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Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in the Gene.
Yu C, Bakshi A, Watts GF, et al. Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in the Gene. Journal of the American Heart Association. 2023;12(21):e031459. doi:10.1161/JAHA.123.031459
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In March of 2020, Ó³»­´«Ã½ converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks.

We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap).

Ó³»­´«Ã½ Genomics Platform sequences a whole human genome every four minutes.

More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research.

The Drug Repurposing Hub is one of the most comprehensive and up-to-date biologically annotated collections of FDA-approved compounds in the world. Researchers anywhere can explore more than 6,000 drugs in the hub and search for possible new uses for them to jump-start new drug discovery.

In 2021, our sustainability efforts sent more than 80 percent of waste from the Genomics Platform to either a recycling facility or to an incineration plant that generates electricity.

Through Ó³»­´«Ã½'s Scientists in the Classroom program, Ó³»­´«Ã½ researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution.

Every summer, 18 high school students spend six weeks at Ó³»­´«Ã½ working side-by-side with mentors on cutting-edge research.

In November 2022, Ó³»­´«Ã½â€™s Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th.

By the end of 2022, Ó³»­´«Ã½â€™s COVID-19 testing lab had processed more than 37 million tests.

Working with Addgene, Ó³»­´«Ã½ has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries.

The NeuroGAP-Psychosis project, a collaboration between the Stanley Center for Psychiatric Research and Harvard T.H. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa.

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