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Describing the genetic architecture of epilepsy through heritability analysis.

Speed D, O’Brien TJ, Palotie A, et al. Describing the genetic architecture of epilepsy through heritability analysis. Brain. 2014;137(Pt 10):2680-9. doi:10.1093/brain/awu206

Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.

Hoggart CJ, Venturini G, Mangino M, et al. Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. PLoS Genet. 2014;10(7):e1004508. doi:10.1371/journal.pgen.1004508

A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.

Traylor M, Mäkelä KM, Kilarski LL, et al. A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. PLoS Genet. 2014;10(7):e1004469. doi:10.1371/journal.pgen.1004469

Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.

Okada Y, Han B, Tsoi LC, et al. Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes. Am J Hum Genet. 2014;95(2):162-72. doi:10.1016/j.ajhg.2014.07.002

Genome-wide association analyses identify variants in developmental genes associated with hypospadias.

Geller F, Feenstra B, Carstensen L, et al. Genome-wide association analyses identify variants in developmental genes associated with hypospadias. Nat Genet. 2014;46(9):957-63. doi:10.1038/ng.3063

Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke.

Tada H, Shiffman D, Smith G, et al. Twelve-single nucleotide polymorphism genetic risk score identifies individuals at increased risk for future atrial fibrillation and stroke. Stroke. 2014;45(10):2856-62. doi:10.1161/STROKEAHA.114.006072

Reconstructing Austronesian population history in Island Southeast Asia.

Lipson M, Loh PR, Patterson N, et al. Reconstructing Austronesian population history in Island Southeast Asia. Nat Commun. 2014;5:4689. doi:10.1038/ncomms5689

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.

Majithia AR, Flannick J, Shahinian P, et al. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proc Natl Acad Sci U S A. 2014;111(36):13127-32. doi:10.1073/pnas.1410428111

Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.

Carneiro M, Rubin CJ, di Palma F, et al. Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. Science. 2014;345(6200):1074-9. doi:10.1126/science.1253714

Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease.

Tada H, Won HH, Melander O, Yang J, Peloso GM, Kathiresan S. Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease. Circ Cardiovasc Genet. 2014;7(5):583-7. doi:10.1161/CIRCGENETICS.113.000420