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Balancing gene expression without library construction via a reusable sRNA pool.

Ghodasara A, Voigt CA. Balancing gene expression without library construction via a reusable sRNA pool. Nucleic Acids Res. 2017;45(13):8116-8127. doi:10.1093/nar/gkx530

Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network.

Dhingra P, Martinez-Fundichely A, Berger A, et al. Identification of novel prostate cancer drivers using RegNetDriver: a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network. Genome Biol. 2017;18(1):141. doi:10.1186/s13059-017-1266-3

Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood.

Edvardson S, Nicolae CM, Agrawal PB, et al. Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood. Am J Hum Genet. 2017;101(2):267-273. doi:10.1016/j.ajhg.2017.07.002

A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus.

Barutcu R, Maass PG, Lewandowski JP, Weiner CL, Rinn JL. A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus. Nat Commun. 2018;9(1):1444. doi:10.1038/s41467-018-03614-0

Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor.

Chen H, Liu S, Padula S, et al. Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor. Nat Biotechnol. 2020;38(2):165-168. doi:10.1038/s41587-019-0331-8

Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.

Herrera KNG, Zaganjor E, Ishikawa Y, et al. Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. Cell Rep. 2018;22(8):1945-1955. doi:10.1016/j.celrep.2018.01.076

Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease.

Baillie K, Bretherick A, Haley CS, et al. Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease. PLoS Comput Biol. 2018;14(3):e1005934. doi:10.1371/journal.pcbi.1005934

Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations.

Fulco CP, Nasser J, Jones TR, et al. Activity-by-contact model of enhancer-promoter regulation from thousands of CRISPR perturbations. Nat Genet. 2019;51(12):1664-1669. doi:10.1038/s41588-019-0538-0

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.

Cho SW, Xu J, Sun R, et al. Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element. Cell. 2018;173(6):1398-1412.e22. doi:10.1016/j.cell.2018.03.068

A Mechano-Activated Cell Reporter System as a Proxy for Flow-Dependent Endothelial Atheroprotection.

Slegtenhorst BR, Ramirez ORF, Zhang Y, Dhanerawala Z, Tullius SG, García-Cardeña G. A Mechano-Activated Cell Reporter System as a Proxy for Flow-Dependent Endothelial Atheroprotection. SLAS Discov. 2018;23(8):869-876. doi:10.1177/2472555218761101