Risk Factors

Late-Onset Crohn's Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics.

Li D, Haritunians T, Landers C, et al. Late-Onset Crohn’s Disease Is A Subgroup Distinct in Genetic and Behavioral Risk Factors With UC-Like Characteristics. Inflamm Bowel Dis. 2018;24(11):2413-2422. doi:10.1093/ibd/izy148

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

Day FR, Thompson DJ, Helgason H, et al. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet. 2017;49(6):834-841. doi:10.1038/ng.3841

Integrative Genetic and Epigenetic Analysis Uncovers Regulatory Mechanisms of Autoimmune Disease.

Shooshtari P, Huang H, Cotsapas C. Integrative Genetic and Epigenetic Analysis Uncovers Regulatory Mechanisms of Autoimmune Disease. Am J Hum Genet. 2017;101(1):75-86. doi:10.1016/j.ajhg.2017.06.001

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.

Zekavat SM, Ruotsalainen S, Handsaker RE, et al. Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018;9(1):2606. doi:10.1038/s41467-018-04668-w

Adherence to a Healthy Lifestyle is Associated With a Lower Risk of Diverticulitis among Men.

Liu PH, Cao Y, Keeley BR, et al. Adherence to a Healthy Lifestyle is Associated With a Lower Risk of Diverticulitis among Men. Am J Gastroenterol. 2017;112(12):1868-1876. doi:10.1038/ajg.2017.398

Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.

Bonàs-Guarch S, Guindo-Martínez M, Miguel-Escalada I, et al. Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. Nat Commun. 2018;9(1):321. doi:10.1038/s41467-017-02380-9

modifies -induced kidney disease risk.

Zhang JY, Wang M, Tian L, et al. modifies -induced kidney disease risk. Proc Natl Acad Sci U S A. 2018;115(13):3446-3451. doi:10.1073/pnas.1716113115

Prospective study of chronotype and incident depression among middle- and older-aged women in the Nurses' Health Study II.

Vetter C, Chang SC, Devore EE, Rohrer F, Okereke OI, Schernhammer ES. Prospective study of chronotype and incident depression among middle- and older-aged women in the Nurses’ Health Study II. J Psychiatr Res. 2018;103:156-160. doi:10.1016/j.jpsychires.2018.05.022

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.

Duncan LE, Ratanatharathorn A, Aiello AE, et al. Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability. Mol Psychiatry. 2018;23(3):666-673. doi:10.1038/mp.2017.77

Inherited DNA-Repair Defects in Colorectal Cancer.

AlDubayan SH, Giannakis M, Moore ND, et al. Inherited DNA-Repair Defects in Colorectal Cancer. Am J Hum Genet. 2018;102(3):401-414. doi:10.1016/j.ajhg.2018.01.018

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