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Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Mol Cell. 2019;73(5):1001-1014.e8. doi:10.1016/j.molcel.2018.11.028

Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate.

Cheng Z, Mugler CF, Keskin A, et al. Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate. Mol Cell. 2019;73(1):36-47.e10. doi:10.1016/j.molcel.2018.10.032

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity.

Vincent BM, Tardiff DF, Piotrowski JS, et al. Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity. Cell Rep. 2018;25(10):2742-2754.e31. doi:10.1016/j.celrep.2018.11.028

Modeling the impact of drug interactions on therapeutic selectivity.

Weinstein ZB, Kuru N, Kiriakov S, et al. Modeling the impact of drug interactions on therapeutic selectivity. Nat Commun. 2018;9(1):3452. doi:10.1038/s41467-018-05954-3

Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast.

Radman-Livaja M, Liu CL, Friedman N, Schreiber SL, Rando OJ. Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast. PLoS Genet. 2010;6(2):e1000837. doi:10.1371/journal.pgen.1000837

Target of rapamycin proteins and their kinase activities are required for meiosis.

Zheng XF, Schreiber SL. Target of rapamycin proteins and their kinase activities are required for meiosis. Proc Natl Acad Sci U S A. 1997;94(7):3070-5.

PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints.

Keith CT, Schreiber SL. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science. 1995;270(5233):50-1.

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

Cimprich KA, Shin TB, Keith CT, Schreiber SL. cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein. Proc Natl Acad Sci U S A. 1996;93(7):2850-5.

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.

Taunton J, Hassig CA, Schreiber SL. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 1996;272(5260):408-11.

Molecular characterization of a FKBP-type immunophilin from higher plants.

Luan S, Kudla J, Gruissem W, Schreiber SL. Molecular characterization of a FKBP-type immunophilin from higher plants. Proc Natl Acad Sci U S A. 1996;93(14):6964-9.