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Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction.

Shi X, Lu C, Corman A, et al. Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction. American journal of human genetics. 2023;110(10):1750-1768. doi:10.1016/j.ajhg.2023.09.004

Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses.

Wan Y, Feng G, Calakos N. Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. J Neurosci. 2011;31(46):16685-91. doi:10.1523/JNEUROSCI.2533-11.2011

All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.

Fan LZ, Nehme R, Adam Y, et al. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods. 2018;15(10):823-831. doi:10.1038/s41592-018-0142-8

Kctd13 deletion reduces synaptic transmission via increased RhoA.

Escamilla CO, Filonova I, Walker AK, et al. Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017;551(7679):227-231. doi:10.1038/nature24470

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission.

Nehme R, Zuccaro E, Ghosh SD, et al. Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell Rep. 2018;23(8):2509-2523. doi:10.1016/j.celrep.2018.04.066

SYT1-associated neurodevelopmental disorder: a case series.

Baker K, Gordon SL, Melland H, et al. SYT1-associated neurodevelopmental disorder: a case series. Brain. 2018;141(9):2576-2591. doi:10.1093/brain/awy209

Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex.

Cottrell JR, Levenson JM, Kim SH, et al. Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex. J Neurosci. 2013;33(27):10938-49. doi:10.1523/JNEUROSCI.5362-12.2013

Development of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neurons.

Chan B, Cottrell JR, Li B, et al. Development of a high-throughput AlphaScreen assay for modulators of synapsin I phosphorylation in primary neurons. J Biomol Screen. 2014;19(2):205-14. doi:10.1177/1087057113505905

Do glia drive synaptic and cognitive impairment in disease?

Chung WS, Welsh CA, Barres BA, Stevens B. Do glia drive synaptic and cognitive impairment in disease? Nat Neurosci. 2015;18(11):1539-1545. doi:10.1038/nn.4142

Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes.

Ren J, Qin C, Hu F, et al. Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron. 2011;69(3):445-52. doi:10.1016/j.neuron.2010.12.038