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The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.

Nechama M, Kwon J, Wei S, et al. The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation. Nat Commun. 2018;9(1):1603. doi:10.1038/s41467-018-03886-6

The classroom microbiome and asthma morbidity in children attending 3 inner-city schools.

Lai PS, Kolde R, Franzosa EA, et al. The classroom microbiome and asthma morbidity in children attending 3 inner-city schools. J Allergy Clin Immunol. 2018;141(6):2311-2313. doi:10.1016/j.jaci.2018.02.022

Gene-Environment Interactions Associated with the Severity of Acute Asthma Exacerbation in Children.

Kantor DB, Phipatanakul W, Hirschhorn JN. Gene-Environment Interactions Associated with the Severity of Acute Asthma Exacerbation in Children. Am J Respir Crit Care Med. 2018;197(5):545-547. doi:10.1164/rccm.201711-2166ED

Phenome-wide association studies across large population cohorts support drug target validation.

Diogo D, Tian C, Franklin CS, et al. Phenome-wide association studies across large population cohorts support drug target validation. Nat Commun. 2018;9(1):4285. doi:10.1038/s41467-018-06540-3

CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata.

Causton B, Pardo-Saganta A, Gillis J, et al. CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata. Am J Respir Cell Mol Biol. 2018;59(6):684-694. doi:10.1165/rcmb.2017-0181OC

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.

Montoro DT, Haber AL, Biton M, et al. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. 2018;560(7718):319-324. doi:10.1038/s41586-018-0393-7

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Demenais F, Margaritte-Jeannin P, Barnes KC, et al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018;50(1):42-53. doi:10.1038/s41588-017-0014-7

RPC4046, A Novel Anti-interleukin-13 Antibody, Blocks IL-13 Binding to IL-13 α1 and α2 Receptors: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation First-in-Human Study.

Tripp CS, Cuff C, Campbell AL, et al. RPC4046, A Novel Anti-interleukin-13 Antibody, Blocks IL-13 Binding to IL-13 α1 and α2 Receptors: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation First-in-Human Study. Adv Ther. 2017;34(6):1364-1381. doi:10.1007/s12325-017-0525-8

Interacting genetic loci cause airway hyperresponsiveness.

Ackerman KG, Huang H, Grasemann H, et al. Interacting genetic loci cause airway hyperresponsiveness. Physiol Genomics. 2005;21(1):105-11. doi:10.1152/physiolgenomics.00267.2004

A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population.

Laitinen T, Daly MJ, Rioux JD, et al. A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population. Nat Genet. 2001;28(1):87-91. doi:10.1038/88319