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The study of structural variation — large-scale changes in DNA that can, in some cases, refashion entire chromosomes — in the genomic era has lagged behind that of sequence variation. But there’s a growing appreciation of how important structural variants are to human biology and disease. What makes these variants more challenging to study, and what is being done to overcome those challenges?

Noncoding mutations in lineage-defining genes could represent a new mutational process in cancer

Primed for self-destruction, testicular cancer cells become drug-resistant as they lose pluripotency factors

Cancer genomics and therapeutics expert returns to academia after decade in industry

A new study of oligodendroglioma at single-cell resolution suggests that stem cells may drive cancer proliferation. 

Using technologies previously developed at the Ó³»­´«Ã½, researchers have analyzed nearly all genetic variants in the oncogene MAPK1/ERK2, revealing insights that could inform treatment.

A crowd-sourcing strategy aimed at accelerating research into metastatic breast cancer has connected advocacy groups, social media, and a dedicated web site to register more than 2,000 patients from all 50 states in its first seven months, say researchers from Dana-Farber Cancer Institute and the Ó³»­´«Ã½ of MIT and Harvard.