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A new study shows that cancer cells across multiple lineages can adopt the same therapy-resistant cell state, enabling broad resistance to targeted therapies. However, the resulting cell circuitry also results in a vulnerability that can be exploited to induce a form of cell death called ferroptosis.

While mutations in protein-coding genes have held the limelight in cancer genomics, those in the noncoding genome (home to the regulatory elements that control gene activity) may  also have powerful roles in driving tumor growth. A new study reveals recurrent mutations in nine such noncoding elements in breast cancer.

New work points to inflammation as key player in heart disease; suggests future potential for screening to reduce risk

Sequencing prostate tumors from African-American men reveals a novel tumor suppressor gene

Building on the success of the Cancer Cell Line Factory, institute researchers will develop 150 cancer models to further the field of precision medicine in an international collaboration.