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Building on the success of the Cancer Cell Line Factory, institute researchers will develop 150 cancer models to further the field of precision medicine in an international collaboration.

The study of structural variation — large-scale changes in DNA that can, in some cases, refashion entire chromosomes — in the genomic era has lagged behind that of sequence variation. But there’s a growing appreciation of how important structural variants are to human biology and disease. What makes these variants more challenging to study, and what is being done to overcome those challenges?

Noncoding mutations in lineage-defining genes could represent a new mutational process in cancer

Primed for self-destruction, testicular cancer cells become drug-resistant as they lose pluripotency factors

Cancer genomics and therapeutics expert returns to academia after decade in industry

A new study of oligodendroglioma at single-cell resolution suggests that stem cells may drive cancer proliferation. 

Using technologies previously developed at the ӳ����ý, researchers have analyzed nearly all genetic variants in the oncogene MAPK1/ERK2, revealing insights that could inform treatment.