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Studies document extent to which common and rare genetic variants work in concert to shape blood traits and disease risk

A better understanding of these changes could one day point to new ways to stop cancer.

In people with a single-gene variant that puts them at high risk for heart disease, breast cancer, or colorectal cancer, the rest of the genome can alter that risk.

Pooled screening in human cells and molecular understanding of Huntington’s disease and pediatric brain cancers. 

International collaboration uncovers biological impacts of common cancer mutations, highlights key features of smoking- and nonsmoking-related lung cancers

Study reveals surprising genomic swapping that underlies clonal hematopoiesis, a condition that can lead to blood cancer and heart disease.

Cancer cells that have lost a copy of a critical gene may be vulnerable to therapies that knock out the remaining copy

Study reveals that ancestry-associated features are found in hundreds of genes, and are closely tied to specific tissues

Single-cell RNA sequencing maps immune microenvironment changes that arise before myeloma appears, and reveals opportunities for developing personalized treatments.

Study suggests chemotherapy itself can cause gliomas to mutate more, and that mutation burden alone is not enough to rouse the immune system against them.