A mere 1% of the human genome encodes protein-coding genes. The remaining non-coding regions are replete with regulatory elements that control gene activity, determine cellular states, and underlie most human diseases.
There has been significant progress towards cataloging these regulatory regions and thereby identifying the working parts of the non-coding genome. These efforts to define a non-coding atlas have made apparent the need to further our understanding of the context-specific functions, mechanisms, and regulatory interactions of each element.