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The study of structural variation — large-scale changes in DNA that can, in some cases, refashion entire chromosomes — in the genomic era has lagged behind that of sequence variation. But there’s a growing appreciation of how important structural variants are to human biology and disease. What makes these variants more challenging to study, and what is being done to overcome those challenges?

InWeb_InBioMap brings together data on more than a half-million protein interactions to put genetic data into functional context and reveal promising pathways for further study.

A search by Ó³»­´«Ã½ researchers and collaborators in the Psychiatric Genomics Consortium for schizophrenia risk factors in genetic data from more than 41,000 people points the finger at gains or losses in eight regions of the genome.

Groundbreaking work is the result of analytical ingenuity, fortuitous collaborations, and catalytic philanthropic funding

We mourn the death of philanthropist Ted Stanley, who passed away on January 4. A successful entrepreneur, Mr. Stanley had a transformative impact on psychiatric disease research through his extraordinary generosity. He was a man of great humility and empathy, who made it his life’s cause to help the millions of people worldwide who suffer from serious psychiatric disease.