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  • Centers
      1. Carlos Slim Center for Health Research The Slim Center aims to bring the benefits of genomics-driven medicine to Latin America, gleaning new insights into diseases with relevance to the region.
      2. Gerstner Center for Cancer Diagnostics The Gerstner Center is developing next-generation diagnostic technology for cancer detection and tracking disease progression.
      3. Klarman Cell Observatory The Klarman Cell Observatory is systematically defining mammalian cellular circuits, how they work together to create tissues and organs, and are perturbed to cause disease.
      4. Merkin Institute for Transformative Technologies in Healthcare The Merkin Institute is supporting early-stage ideas aimed at advancing powerful technological approaches for improving how we understand and treat disease.
      5. Novo Nordisk Foundation Center for Genomic Mechanisms of Disease This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the ӳý and the Danish research community.
      6. Eric and Wendy Schmidt Center The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health.
      7. Stanley Center for Psychiatric Research The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments.
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      1. Art and science connection Explore the connection between art and science and how we bring together artists and ӳý scientists through our artist-in-residence program, gallery exhibitions, and ongoing public conversations.
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News

2021

  • Tackling diabetes from every angle

 

2020

  • Dozens of non-oncology drugs can kill cancer cells
  • How a lung injury study helped inspire new COVID-19 drug trials
  • New genetic vulnerability found in upwards of a third of all cancers

 

2019

  • Loss of a DNA repair system creates a unique vulnerability in many cancer types
  • Massive sequencing study links rare DNA alterations to type 2 diabetes
  • A molecular traffic jam may underlie a rare kidney disease and several other protein misfolding disorders

 

2018

  • Upgraded computational tool boosts search for cancer vulnerabilities

 

2017

  • The breast cancer genome’s “dark matter” starts to give up some secrets
  • Turning risk-association to biological insight in T2D
  • After a decade of genome-wide association studies, a new phase of discovery pushes on

 

2014

  • International team unearths strong genetic risk factor for type 2 diabetes in Latin American populations

 

2013

  • International team completes systematic, genomic study of cervical cancer
  • New genetic risk factor for type 2 diabetes revealed
  • Mexico-US genomics partnership launches second phase
  • Bringing out the usual – and unusual – cancer genomics suspects
  • Kidney disease mutations found in a genomic blind spot

 

2012

  • Two-way exchange
  • Breast cancer’s many drivers

 

2011

  • Convergence in head and neck cancer

 

2010

  • Mexico-US collaboration launched

SIGMA

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    • Cancer
    • Diabetes
    • Kidney Disease
  • Building Scientific Capacity
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    • El Centro Carlos Slim para la Investigación en Salud

Latest news

Illustration of a boxy robot with green eyes printing long pages of DNA sequences.
News 01.23.2026
AI generates short DNA sequences that show promise for gene therapies
Graphic depicts a small molecule as a chemical structure bound to a larger molecule.
News 01.16.2026
Scientists develop molecules that may treat Crohn’s disease
A spatial image of a sample of intestinal tissue from a patient with ulcerative colitis, showing individual cells as colored dots in layers of tissue on a white background.
News 01.07.2026
Researchers uncover molecular roots of fibrosis or tissue scarring in inflammatory bowel disease
A microscopic image of liver tissue, colored pink, affected by non-alcoholic fatty liver disease (NAFLD), showing large fat droplets, colored white, filling the liver cells
News 12.22.2025
High-fat diets make liver cells more likely to become cancerous
All news

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ӳý's gene-editing technologies—CRISPR-Cas9, base editing, and prime editing—are being tested in more than 25 clinical trials to treat or cure leukemias, rare genetic diseases, high cholesterol, and other conditions.

NIH-funded discoveries from the ӳý are powering nearly 20 clinical trials from companies testing new treatments for diseases like cancer and heart disease.

ӳý developed a technology — partly supported by NIH funding —  that can detect trace amounts of cancer DNA from blood tests and help cancer patients find out their risk of disease recurrence earlier.

Using NIH funding, the ӳý’s Rare Genomes Project has worked with more than 1,300 families from all 50 U.S. states to diagnose rare genetic diseases.

ӳý Clinical Labs has directly partnered with tens of thousands of cancer patients to analyze their DNA and accelerate research.

During the COVID-19 pandemic, ӳý launched a large-scale diagnostic testing lab that processed over 37 million tests and saved state and federal programs nearly $2 billion.

The ӳý's Cancer Dependency Map helps cancer researchers and drug developers discover therapeutic targets for new cancer treatments.

gnomAD, a large human genetic variant reference database developed by the ӳý with NIH funding, has contributed to over 13 million genetic disease diagnoses since its launch in 2014.

Datasets generated at the ӳý were used to train AlphaGenome, a cutting-edge AI model from Google DeepMind that predicts how genetic variants affect gene regulation.

the FDA granted accelerated approval for a lung cancer drug that was developed with ӳý science and is for patients who otherwise had few treatment options.

David Liu and his team used NIH funding to invent precise gene-editing technologies, including one that may vastly improve access to genetic therapies for patients with rare disease.

NIH-funded ӳý research is shedding new light on the biological roots of many diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease.

Scientists with ӳý’s Stanley Center for Psychiatric Research have found key genetic factors for schizophrenia and bipolar disorder.

ӳý scientists are using AI to design new antibiotics and other drugs, predict drug toxicity, and pinpoint genes, molecules, and cells that might be causing disease.

ӳý Clinical Labs has sequenced nearly 900,000 whole human genomes, producing, on average, one human genome sequence every three minutes.

ӳý Clinical Labs developed a new method for genome sequencing that costs 75 percent less than existing methods.

 ӳý Clinical Labs is the largest genome sequencing center of its kind in the world.

ӳý Clinical Labs has partnered with MyOme and Southern Research Institute in Birmingham, Alabama to provide free genetic tests to people in Alabama.

ӳý Clinical Labs has partnered with Mass General Brigham and Everygene to provide no-cost genetic testing to people throughout the US with cardiomyopathy, a disorder that can cause sudden cardiac death.

ӳý Clinical labs and Mass General Brigham used data from NIH’s All of Us program to develop a genetic test that predicts risk of eight different heart conditions. This test is now available to patients.

Thanks to NIH funding, ӳý Clinical Labs is collaborating with scientists across the U.S. to sequence DNA from tens of thousands of children with cancer and birth defects to study common biological pathways.

ӳý Clinical Labs holds the world record for fastest DNA sequencing, completing whole genome sequencing and analysis in less than four hours at their facility in Burlington, Massachusetts.

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