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Synergy between two large cancer datasets may help identify a targetable weakness across many cancers

When making a simple telescope, relative adjustments between two lenses can bring previously blurry objects sharply into focus. Peering through two such “lenses” recently led to a discovery that may help identify which patients could most benefit from taking aim at a potentially widespread cancer therapeutic target.

Cancers can be cunning beasts and one of their favorite opportunities is something called a chromosomal translocation. Chromosomes are the 23 packages in every cell of condensed DNA. Translocations happen when the DNA breaks and the ends reattach elsewhere. DNA breakage actually occurs somewhat frequently, even in healthy individuals. But a series of ancient and very smart cellular processes ensure that things get put back in the right place — except when they don’t.

Protein interactions via a new type of biochemistry- one-dimensional biochemistry

ӳý core institute member Paul Blainey recalls that toward the end of his graduate training in Chemistry and Chemical Biology at Harvard nearly a decade ago, things became really interesting. He got a request for help from a scientist who studies viruses that would later lead to their discovery of a new vehicle for intracellular transport dubbed a “molecular sled” and help chart the path of Blainey’s own scientific career.