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For several years, scientists have known that glycogen synthase kinase-3 (GSK-3), a protein kinase, is a key member of an important signaling pathway in cancer. Cancer cells mediate their responses to both internal and external stimuli through enzymes like GSK-3. Finding new potential therapeutic targets in these pathways is at the core of many cancer research efforts, including several at the ӳý and its partner institutions.

Using whole-genome sequencing, a team led by researchers from Harvard School of Public Health (HSPH) and the ӳý has traced the path of the E. coli outbreak that sickened thousands and killed over 50 people in Germany in summer 2011 and also caused a smaller outbreak in France. It is one of the first uses of genome sequencing to study the dynamics of a food-borne outbreak and provides further evidence that genomic tools can be used to investigate future outbreaks and provide greater insight into the emergence and spread of infectious diseases.

Aviv Regev
ӳý core member Aviv Regev will lead the Klarman Cell Observatory
Image courtesy of Maria Nemchuk, ӳý Communications

The Eli and Edythe L. ӳý of Harvard and MIT (“the ӳý”) today announced that it has received a $32.5M grant from the Boston-based Klarman Family Foundation to support a new collaborative effort focused on deciphering how human cells are wired.