Earlier this month, researchers from the ӳý and Massachusetts General Hospital (MGH) published a paper in Nature Methods about a new approach to an established technique. The technique is called ChiP-seq, short for chromatin immunoprecipitation with high-throughput sequencing, and is used to study how protein and DNA interact. The paper's authors are postdoctoral scholars Mazhar Adli and Jiang Zhu and ӳý associate member Brad Bernstein. Brad answered five of our questions about his latest paper and his field of interest.